[前列腺腺癌核仁组成区与 Gleason 系统的相关性]

[Correlation between the nucleolar organizer region in adenocarcinoma of the prostate and the Gleason system].

作者信息

Sentinelli S, Pizzuti V, Rondanelli E, Viggiani F, Paolini R

机构信息

U.O. di anatomia patologica, Ospedale generale provinciale Misericordia, Grosseto.

出版信息

Pathologica. 1992 Jan-Feb;84(1089):49-55.

PMID:1379709

Abstract

Using a silver staining, technique, Nucleolar Organizer Region-associated proteins (NORs) were studied on paraffin sections of 25 resected prostatic adenocarcinomas classified with Gleason grading and 11 hyperplastic lesions. Then 7 inclusions was selected for each grade of Gleason system and 7 inclusions of normal prostatic tissue. The mean numbers of argyrophilic nucleolar organizer regions (AgNORs) increased significantly (P less than 0.01) from normal prostatic tissue to Gleason 5. The data indicate that AgNORs counts may help distinguish between each grade of Gleason system. It was concluded that the AgNOR technique provides a significant kinetic evaluation of prostatic adenocarcinoma and its prognostic study.

摘要

采用银染色技术，对25例经Gleason分级的前列腺腺癌切除石蜡切片及11例增生性病变进行核仁组织区相关蛋白（NORs）研究。然后，从Gleason系统的每个分级中选取7个样本，并选取7个正常前列腺组织样本。从正常前列腺组织到Gleason 5级，嗜银核仁组织区（AgNORs）的平均数量显著增加（P小于0.01）。数据表明，AgNORs计数可能有助于区分Gleason系统的各个分级。得出结论，AgNOR技术为前列腺腺癌提供了重要的动力学评估及其预后研究。