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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Yamashita H, Sato N, Yamamoto M, Sato Y, Nakanishi K, Suzuki M, Habara Y, Ohno H

Department of Hygiene, National Defense Medical College, Tokorozawa, Japan.

Comp Biochem Physiol Comp Physiol. 1992 Dec;103(4):673-8. doi: 10.1016/0300-9629(92)90165-m.

An apparent effect of insulin administration on enlargement of interscapular brown adipose tissue (BAT) was found in heat-exposed rats, but not in warm-adapted or cold-acclimated rats. 2. BAT extracts from the heat-acclimated/insulin-treated (HI) rats notably increased the capillary growth in an in vitro angiogenesis model in which microvascular fragments and myofibroblastic (Mf) cells isolated from lipid tissues were grown in co-culture, although a direct effect of insulin was not high. 3. BAT extracts from the HI rats stimulated the production of endothelial cell growth factor and collagen by Mf cells. 4. It is probable that an increased angiogenic activity contributes to the capillary growth and tissue growth in BAT of HI rats.

在受热暴露的大鼠中发现胰岛素给药对肩胛间棕色脂肪组织（BAT）的增大有明显作用，但在适应温暖环境或冷适应的大鼠中未发现此现象。2. 热适应/胰岛素处理（HI）大鼠的BAT提取物在体外血管生成模型中显著增加了毛细血管生长，在该模型中，从脂质组织分离的微血管片段和成肌纤维细胞（Mf）共同培养生长，尽管胰岛素的直接作用不高。3. HI大鼠的BAT提取物刺激了Mf细胞产生内皮细胞生长因子和胶原蛋白。4. 血管生成活性增加可能有助于HI大鼠BAT中的毛细血管生长和组织生长。

Yamashita H, Sato N, Yamamoto M, Sato Y, Nakanishi K, Suzuki M, Habara Y, Ohno H

Department of Hygiene, National Defense Medical College, Tokorozawa, Japan.

Comp Biochem Physiol Comp Physiol. 1992 Dec;103(4):673-8. doi: 10.1016/0300-9629(92)90165-m.

An apparent effect of insulin administration on enlargement of interscapular brown adipose tissue (BAT) was found in heat-exposed rats, but not in warm-adapted or cold-acclimated rats. 2. BAT extracts from the heat-acclimated/insulin-treated (HI) rats notably increased the capillary growth in an in vitro angiogenesis model in which microvascular fragments and myofibroblastic (Mf) cells isolated from lipid tissues were grown in co-culture, although a direct effect of insulin was not high. 3. BAT extracts from the HI rats stimulated the production of endothelial cell growth factor and collagen by Mf cells. 4. It is probable that an increased angiogenic activity contributes to the capillary growth and tissue growth in BAT of HI rats.

在受热暴露的大鼠中发现胰岛素给药对肩胛间棕色脂肪组织（BAT）的增大有明显作用，但在适应温暖环境或冷适应的大鼠中未发现此现象。2. 热适应/胰岛素处理（HI）大鼠的BAT提取物在体外血管生成模型中显著增加了毛细血管生长，在该模型中，从脂质组织分离的微血管片段和成肌纤维细胞（Mf）共同培养生长，尽管胰岛素的直接作用不高。3. HI大鼠的BAT提取物刺激了Mf细胞产生内皮细胞生长因子和胶原蛋白。4. 血管生成活性增加可能有助于HI大鼠BAT中的毛细血管生长和组织生长。