Bégin-Heick N, Noland I, Dalpé M, Heick H M
Can J Physiol Pharmacol. 1979 Mar;57(3):320-4. doi: 10.1139/y79-049.
Data are presented indicating that in brown adipose tissue (BAT) of cold-acclimated (CA), but not cold-exposed (CE) rats, there was an alteration in the relative response to catecholamines and insulin as evidenced by increased binding of alprenolol and decreased binding of insulin to plasma membrane enriched fractions. In addition, the stimulatory effect of insulin on glucose incorporation into glycogen and its inhibitory action on adenylate cyclase activity were both blunted in the CA tissues. It is proposed that shifts in the capacity of BAT to respond to catecholamines and insulin may be involved in the mechanism of cold acclimation.
所呈现的数据表明，在冷适应（CA）而非冷暴露（CE）大鼠的棕色脂肪组织（BAT）中，对儿茶酚胺和胰岛素的相对反应发生了改变，这表现为阿普洛尔结合增加以及胰岛素与富含质膜的组分结合减少。此外，在冷适应组织中，胰岛素对葡萄糖掺入糖原的刺激作用及其对腺苷酸环化酶活性的抑制作用均减弱。有人提出，棕色脂肪组织对儿茶酚胺和胰岛素反应能力的变化可能参与了冷适应机制。
