替利霉素对从患有侵袭性和非侵袭性感染的法国儿童中分离出的耐青霉素肺炎链球菌菌株的活性。
Activity of telithromycin against penicillin-resistant Streptococcus pneumoniae isolates recovered from French children with invasive and noninvasive infections.
作者信息
Bingen Edouard, Doit Catherine, Loukil Chawki, Brahimi Naima, Bidet Philippe, Deforche Dominique, Geslin Pierre
机构信息
Service de Microbiologie, Hôpital Robert Debré, Paris, France.
出版信息
Antimicrob Agents Chemother. 2003 Jul;47(7):2345-7. doi: 10.1128/AAC.47.7.2345-2347.2003.
Abstract
We compared the activities of telithromycin, erythromycin, azithromycin, josamycin, penicillin G, amoxicillin, cefpodoxime, and ceftriaxone against invasive and noninvasive non-penicillin-susceptible Streptococcus pneumoniae isolates recovered from children. Of the 186 isolates tested, 89% were positive for erm(B) by PCR. Telithromycin had the lowest MICs, with MICs at which 90% of the isolates tested are inhibited of 0.032 and 0.25 micro g/ml for erythromycin-sensitive and -resistant isolates, respectively.
摘要
我们比较了泰利霉素、红霉素、阿奇霉素、交沙霉素、青霉素G、阿莫西林、头孢泊肟和头孢曲松对从儿童中分离出的侵袭性和非侵袭性非青霉素敏感肺炎链球菌菌株的活性。在测试的186株菌株中，89%经聚合酶链反应检测erm(B)呈阳性。泰利霉素的最低抑菌浓度最低，对于红霉素敏感和耐药菌株，使90%测试菌株受到抑制的最低抑菌浓度分别为0.032和0.25微克/毫升。
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