肺炎链球菌对青霉素、阿奇霉素和泰利霉素的敏感性（PROTEKT 1999 - 2003）
Susceptibility of Streptococcus pneumoniae to penicillin, azithromycin and telithromycin (PROTEKT 1999-2003).
作者信息
Schito G C, Felmingham D
机构信息
Institute of Microbiology, University of Genoa Medical School, Largo Rosanna Benzi 10, 16132 Genoa, Italy.
出版信息
Int J Antimicrob Agents. 2005 Dec;26(6):479-85. doi: 10.1016/j.ijantimicag.2005.04.022. Epub 2005 Nov 9.
Isolates of Streptococcus pneumoniae collected over the first 4 years of the PROTEKT study were tested for susceptibility to penicillin, azithromycin and telithromycin. A total of 20,750 isolates were collected from 39 countries. Penicillin non-susceptibility rates were stable over the study period; overall, 21.8% of isolates were resistant. Azithromycin resistance increased from 31.0% in Year 1 to 36.3% in Year 4. Resistance rates for penicillin and azithromycin varied between countries and were highest in France, Spain, South Africa, USA and the Far East. Multidrug resistance in S. pneumoniae did not change significantly over the 4 years, with an overall rate of 38.6%. Telithromycin retained good activity against S. pneumoniae (0.1% of isolates resistant), including multidrug-resistant isolates.
对在PROTEKT研究的头4年收集的肺炎链球菌分离株进行了青霉素、阿奇霉素和泰利霉素敏感性测试。共从39个国家收集了20750株分离株。在研究期间，青霉素不敏感率保持稳定；总体而言，21.8%的分离株具有耐药性。阿奇霉素耐药率从第1年的31.0%上升至第4年的36.3%。青霉素和阿奇霉素的耐药率因国家而异，在法国、西班牙、南非、美国和远东地区最高。肺炎链球菌的多重耐药性在4年中没有显著变化，总体发生率为38.6%。泰利霉素对肺炎链球菌仍保持良好活性（0.1%的分离株耐药），包括多重耐药分离株。
Zotero 插件