肿瘤抑制性N-（双-（2-氯乙基）-氨甲基）-脲烷（作者译）
[Tumour inhibitory N-(bis--(2-chlorethyl)-aminomethyl)-urethanes (author's transl)].
作者信息
Schïnenberger H, Schmidt F, Bindl L
出版信息
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Nov 25;84(3):277-40.
PMID:128219
Abstract
The synthesis of N-[bis-(2-chlorethyl)-aminomethyl]-urethanes (I-VI) and N,N'-di[bis-(2-chlorethyl)-aminomethyl]-urea (VII) and their evaluation on the Yoshida sarcoma of the rat and on the sarcoma 180 of the mouse are described. The antitumor activity of I-VI is based on a reaction mechanism analogous to that of aromatic N-lost-derivatives.
摘要
描述了N-［双-（2-氯乙基）-氨甲基］-脲烷（I-VI）和N，N'-二［双-（2-氯乙基）-氨甲基］-脲（VII）的合成及其对大鼠吉田肉瘤和小鼠肉瘤180的评价。I-VI的抗肿瘤活性基于一种类似于芳香族N-去甲衍生物的反应机制。
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[Tumour inhibitory N-(bis--(2-chlorethyl)-aminomethyl)-urethanes (author's transl)].肿瘤抑制性N-（双-（2-氯乙基）-氨甲基）-脲烷（作者译）
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Nov 25;84(3):277-40.
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