[Synthesis and antitumor action of N,N-di(2-chlorethyl)-hydrazines of alpha-aminocarboxylic acid antimetabolites].
作者信息
Zakhariev S, Golovinsky E, Stoev S, Maneva L, Aleksiev B
机构信息
Institut für Molekularbiologie der Bulgarischen Akademie der Wissenschaften Chemisch-technologische Hochschule, Sofia, VR Bulgarien.
出版信息
Pharmazie. 1989 Aug;44(8):542-4.
PMID:2594824
Abstract
The N,N-di(2-chlorethyl)hydrazides of the following alpha-aminocarboxylic acid antimetabolites: methioninsulphoxide, ethionine, 2-, 3- and 4-fluorophenylalanine, 4-nitrophenylalanine and 2,2-dimethyl-thiazolidine-4-carboxylic acid were synthesized. Preliminary studies of the activity on experimental tumour models were carried out. It was shown that these compounds have a high antitumour effect (80-100%) on sarcoma Yoshida and carcinosarcoma Walker.
摘要
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