Iuldasheva I A, Aripova M I
Klin Lab Diagn. 2003 May(5):3-5.
Bronchoalveolar lavage (BAL) was studied in 16 patients with bronchial asthma. Overall metabolites of nitric oxide and malonic dialdehyde were measured. Correlations were established between the concentrations of biologically active compounds and lung ventilation in exacerbation and remission. Lipid peroxidation is closely related with inflammation in both the disease and in health, and is not related with disorders in lung ventilation. Nitric oxide metabolites are different: gas secretion in the exacerbation of bronchial asthma is higher than in chronic obstructive bronchitis. In remission, the nitric oxide activity is low, while it was higher in patients with bronchial asthma as compared with healthy persons.
对16例支气管哮喘患者进行了支气管肺泡灌洗（BAL）研究。测定了一氧化氮和丙二醛的总体代谢产物。建立了生物活性化合物浓度与疾病加重期和缓解期肺通气之间的相关性。脂质过氧化在疾病和健康状态下均与炎症密切相关，与肺通气障碍无关。一氧化氮代谢产物有所不同：支气管哮喘加重期的气体分泌高于慢性阻塞性支气管炎。在缓解期，一氧化氮活性较低，而与健康人相比，支气管哮喘患者的一氧化氮活性较高。
