Kulakova N V, Nevzorova V A, Luk'ianov P A, Gel'tser B I
Klin Med (Mosk). 2000;78(3):36-9.
Bronchoalveolar lavage (BAL) was studied in 139 patients with chronic obstructive pulmonary diseases (COPD). 90 of them had chronic bronchitis, 35--bronchial asthma. Overall metabolites of nitric oxide, histamine, serotonin, malonic dialdehyde were measured. Correlations were studied between concentrations of biologically active compounds and lung ventilation in exacerbation and remission. It was found that levels of indolalkylamines change in one direction both in inflammation and bronchial obstruction. Lipid peroxidation in BAL is closely connected with inflammation in both the diseases and is not related with disorders in lung ventilation. Nitric oxide metabolites differed: gas secretion in bronchial asthma exacerbation is higher than in chronic obstructive bronchitis. In its remission, nitric oxide activity is low, while in bronchial asthma it persisted higher than in healthy subjects.
对139例慢性阻塞性肺疾病（COPD）患者进行了支气管肺泡灌洗（BAL）研究。其中90例患有慢性支气管炎，35例患有支气管哮喘。检测了一氧化氮、组胺、血清素、丙二醛的总体代谢产物。研究了生物活性化合物浓度与病情加重期和缓解期肺通气之间的相关性。结果发现，在炎症和支气管阻塞时，吲哚烷基胺水平均朝同一方向变化。BAL中的脂质过氧化与这两种疾病的炎症密切相关，与肺通气障碍无关。一氧化氮代谢产物有所不同：支气管哮喘加重期的气体分泌高于慢性阻塞性支气管炎。在缓解期，一氧化氮活性较低，而在支气管哮喘中，其活性持续高于健康受试者。
