de Greeff S C, de Melker H E, Spanjaard L, van den Hof S, Dankert J
Rijksinstituut voor Volksgezondheid en Milieu, Centrum voor Infectieziekten Epidemiologie, Postbus 1, 3720 BA Bilthoven.
Ned Tijdschr Geneeskd. 2003 Jun 7;147(23):1132-5.
To describe the initial effects of the large-scale vaccination campaign in June-July of 2002 (1-5- and 15-18-year-olds) and September-November of 2002 (6-14-year-olds) on the incidence of group-C meningococcal disease in the Netherlands.
Descriptive.
The incidence of meningococcal disease and the serogroup distribution were determined on the basis of the patient data associated with isolates of Neisseria meningitidis that were sent to the Netherlands Reference Laboratory for Bacterial Meningitis during the period from 1 January 1999 to 31 January 2003.
The highest monthly incidence of serogroup-C disease was reported in January-April 2002 (2.2-3.1/100,000), after which the incidence remained more or less unchanged after September at a level of 0.1-0.4/100,000. The incidence of meningococcal-C disease was 73% lower in August-October 2002 compared with the same period in 2001. In the same months, the incidence of meningococcal-C disease for the 0, 1-5, 6-14, 15-18 and > 18 year-olds was 49%, 80%, 89%, 89% and 42%, respectively, lower than in the same months in the previous year. The percentage of meningococcal disease caused by serogroup-C fluctuated from 35 to 49% in January-August 2002 and decreased to 9-19% in September-December 2002. There was also a decrease in the unvaccinated age groups.
The vaccination campaign led almost immediately to a sharp decrease in the number of patients with meningococcal serogroup-C disease.
描述2002年6月至7月（1 - 5岁及15 - 18岁人群）和2002年9月至11月（6 - 14岁人群）大规模疫苗接种运动对荷兰C群脑膜炎球菌病发病率的初步影响。
描述性研究。
根据1999年1月1日至2003年1月31日期间送往荷兰细菌性脑膜炎参考实验室的脑膜炎奈瑟菌分离株相关的患者数据，确定脑膜炎球菌病的发病率和血清群分布。
2002年1月至4月报告的C群疾病月发病率最高（2.2 - 3.1/10万），此后9月之后发病率基本保持不变，维持在0.1 - 0.4/10万的水平。2002年8月至10月，脑膜炎球菌C群疾病的发病率比2001年同期低73%。在同一时期，0岁、1 - 5岁、6 - 14岁、15 - 18岁及18岁以上人群的脑膜炎球菌C群疾病发病率分别比上一年同期低49%、80%、89%、89%和42%。2002年1月至8月，C群引起的脑膜炎球菌病百分比在35%至49%之间波动，2002年9月至12月降至9%至19%。未接种疫苗的年龄组发病率也有所下降。
疫苗接种运动几乎立即导致脑膜炎球菌C群疾病患者数量急剧下降。
