Dubay Derek A, Franz Michael G
Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
Surg Clin North Am. 2003 Jun;83(3):463-81. doi: 10.1016/S0039-6109(02)00196-2.
Acute wound healing failure is an important source of morbidity and mortality for surgical patients. Many incisional hernias, gastrointestinal anastomotic leaks, and vascular pseudoaneurysms occur despite patient optimization and standardized surgical technique. Modern surgical experience suggests that biologic and mechanical pathways overlap during "normal" acute wound healing. The cellular and molecular processes activated to repair tissue from the moment of injury are under the control of biologic and mechanical signals. Successful acute wound healing occurs when a dynamic balance is met between the loads placed across a provisional matrix and the feedback and feed-forward responses of repair cells.
急性伤口愈合失败是外科患者发病和死亡的重要原因。尽管对患者进行了优化并采用了标准化手术技术，但仍会出现许多切口疝、胃肠道吻合口漏和血管假性动脉瘤。现代外科经验表明，在“正常”急性伤口愈合过程中，生物途径和机械途径相互重叠。从受伤那一刻起被激活以修复组织的细胞和分子过程受生物和机械信号的控制。当跨越临时基质的负荷与修复细胞的反馈和前馈反应之间达到动态平衡时，急性伤口才能成功愈合。
