Petrie Nicola C, Yao Feng, Eriksson Elof
Laboratory of Wound Repair and Gene Transfer, Division of Plastic Surgery, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Surg Clin North Am. 2003 Jun;83(3):597-616, vii. doi: 10.1016/S0039-6109(02)00194-9.
Gene therapy is a new and emerging technology that has been catalyzed by the progress of the Human Genome Project. It employs the process of manipulating genes to achieve a clinically beneficial alteration in gene product. Wound healing lends itself to the application of gene therapy by virtue of the vast array of proteins involved in its complex cascade. This article provides an overview of the background to gene therapy and describes current techniques in use as applied to wound healing. The authors show the potential role that many candidate genes may offer in the future for optimizing wound healing through gene therapy.
基因治疗是一项新兴技术，人类基因组计划的进展推动了它的发展。它通过操纵基因的过程来实现基因产物临床上有益的改变。伤口愈合因其复杂级联反应中涉及大量蛋白质而适合应用基因治疗。本文概述了基因治疗的背景，并描述了目前应用于伤口愈合的技术。作者展示了许多候选基因未来可能通过基因治疗在优化伤口愈合方面发挥的潜在作用。
