Promphan Worakan, Khongphatthanayothin Apichai, Horchaiprasit Kriangsak, Benjacholamas Vichai
Division of Pediatric Cardiology, Department of Pediatrics, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Pacing Clin Electrophysiol. 2003 Jun;26(6):1424-6. doi: 10.1046/j.1460-9592.2003.t01-1-00204.x.
We reported a 6-year-old girl who developed torsade de pointes (TdP) after taking roxithromycin. The patient had congenital complete heart block and complex cyanotic heart disease. Before taking roxithromycin, her corrected QT interval (QTc) was 0.39 second with a ventricular rate of 55-60 beats/min. Repetitive bursts of TdP with prolonged QT interval (QTc = 0.55 s) developed after taking roxithromycin. After stopping the medication, her QT interval normalized (QTc = 0.38 s). This case demonstrated the potential of roxithromycin in causing TdP especially in a patient with other risk factors for prolong QT interval and TdP.
我们报告了一名6岁女孩，她在服用罗红霉素后发生了尖端扭转型室性心动过速（TdP）。该患者患有先天性完全性心脏传导阻滞和复杂性青紫型心脏病。在服用罗红霉素之前，她的校正QT间期（QTc）为0.39秒，心室率为55 - 60次/分钟。服用罗红霉素后出现了伴有QT间期延长（QTc = 0.55秒）的反复TdP发作。停药后，她的QT间期恢复正常（QTc = 0.38秒）。该病例表明罗红霉素有致TdP的可能性，尤其是在有其他QT间期延长和TdP危险因素的患者中。
