Heyer G
Department of Dermatology, University Erlangen-Nürnberg, Germany.
Acta Derm Venereol Suppl (Stockh). 1992;176:93-4.
Having found an inability of patients with atopic eczema to distinguish different levels of iontophoretically applied histamine concentrations, as shown by their diminished vascular reactions and itch responses, and reviewing this result in the light of our new findings of smaller flare reactions and weaker itch sensations following different concentrations of intradermally injected substance P, we have concluded that unmyelinated afferent skin nerve fibres in these patients seem to be affected by the pathophysiological mechanism of atopic eczema. We therefore suspect that a down-regulation of histamine receptors at nerve endings compensates for elevated histamine release from cutaneous mast cells in patients with atopic eczema.
已发现特应性皮炎患者无法区分离子电渗法施加的不同浓度组胺，这表现为他们血管反应和瘙痒反应减弱。鉴于我们新的研究结果，即皮内注射不同浓度的P物质后出现较小的风团反应和较弱的瘙痒感，重新审视这一结果后，我们得出结论，这些患者无髓传入皮肤神经纤维似乎受到特应性皮炎病理生理机制的影响。因此，我们怀疑特应性皮炎患者神经末梢组胺受体的下调可补偿皮肤肥大细胞组胺释放的增加。
