Herath W H M W, Ferreira D, Khan I A
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, USA.
Nat Prod Res. 2003 Aug;17(4):269-74. doi: 10.1080/1057563021000060158.
The phthalideisoquinoline alkaloid (-)-beta-hydrastine is one of the main active constituents of the medicinal plant, Hydrastis canadensis, which is used in many dietary supplements intended to enhance the immune system. Treatment of hydrastine with the fermentation broth of Polyporous brumalis (ATCC 34487) as a model for mammalian metabolism, gave a new alkaloid, (1S)-hydroxyhydrastine. Structure elucidation was based primarily on NMR and chiroptical studies.
酞嗪异喹啉生物碱（-）-β-白毛茛碱是药用植物白毛茛的主要活性成分之一，白毛茛被用于许多旨在增强免疫系统的膳食补充剂中。以多孔侧耳（ATCC 34487）的发酵液作为哺乳动物代谢模型对白毛茛碱进行处理，得到了一种新的生物碱，即（1S）-羟基白毛茛碱。结构解析主要基于核磁共振（NMR）和旋光光谱研究。
