Cases Ildefonso, de Lorenzo Victor, Ouzounis Christos A
Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK.
Trends Microbiol. 2003 Jun;11(6):248-53. doi: 10.1016/s0966-842x(03)00103-3.
Lifestyle can be viewed as the environment surrounding an organism and the relationships that it establishes with other species. It is one of the driving forces that contribute to the final shape of bacterial genomes. To assess how these forces affect global cellular functions, we investigated the fraction of the genome devoted to transcription-related proteins, small-molecule metabolism enzymes, and transport, for 60 bacterial genomes classified by lifestyle. Larger genomes were found to harbour more transcription factors per gene than smaller ones. In addition, free-living bacteria (with a few exceptions) are clearly enriched for transcription factors, beyond the expected proportion based on their genome size. This suggests that under complex conditions, gene expression regulation and signal integration have been strongly selected for to enable rapid adaptation to environmental conditions.
生活方式可被视为生物体周围的环境以及它与其他物种建立的关系。它是促成细菌基因组最终形态的驱动力之一。为了评估这些力量如何影响细胞整体功能，我们针对按生活方式分类的60个细菌基因组，研究了基因组中用于转录相关蛋白、小分子代谢酶和转运的部分。发现较大的基因组比较小的基因组每个基因含有更多的转录因子。此外，自由生活的细菌（有少数例外）明显富含转录因子，超出了基于其基因组大小所预期的比例。这表明在复杂条件下，基因表达调控和信号整合已被强烈选择以实现对环境条件的快速适应。
