Gohar Daniyal, Põldmaa Kadri, Pent Mari, Rahimlou Saleh, Cerk Klara, Ng Duncan Y K, Hildebrand Falk, Bahram Mo
Institute of Ecology and Earth Sciences, University of Tartu, J. Liivi St. 2, 50409 Tartu, Estonia.
Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA.
iScience. 2025 Mar 20;28(4):112253. doi: 10.1016/j.isci.2025.112253. eCollection 2025 Apr 18.
Fungi harbor diverse bacteria that engage in various relationships. While these relationships potentially influence fungal functioning, their underlying genetic mechanisms remain unexplored. Here, we aimed to elucidate the key genomic features of fungus-associated bacteria (FaB) by comparing 163 FaB genomes to 1,048 bacterial genomes from other hosts and habitats. Our analyses revealed several distinctive genomic features of FaB. We found that FaB are enriched in carbohydrate transport/metabolism- and motility-related genes, suggesting an adaptation for utilizing complex fungal carbon sources. They are also enriched in genes targeting fungal biomass, likely reflecting their role in recycling and rebuilding fungal structures. Additionally, FaB associated with plant-mutualistic fungi possess a wider array of carbon-acquisition enzymes specific to fungal and plant substrates compared to those residing with saprotrophic fungi. These unique genomic features highlight FaB' potential as key players in fungal nutrient acquisition and decomposition, ultimately influencing plant-fungal symbiosis and ecosystem functioning.
真菌携带着多种细菌，它们之间存在着各种关系。虽然这些关系可能会影响真菌的功能，但其潜在的遗传机制仍未得到探索。在这里，我们旨在通过将163个真菌相关细菌（FaB）基因组与来自其他宿主和栖息地的1048个细菌基因组进行比较，阐明真菌相关细菌（FaB）的关键基因组特征。我们的分析揭示了FaB的几个独特基因组特征。我们发现，FaB在碳水化合物运输/代谢和运动相关基因中富集，这表明它们适应利用复杂的真菌碳源。它们在靶向真菌生物量的基因中也很丰富，这可能反映了它们在真菌结构循环和重建中的作用。此外，与腐生真菌相比，与植物共生真菌相关的FaB拥有更广泛的针对真菌和植物底物的碳获取酶。这些独特的基因组特征凸显了FaB作为真菌养分获取和分解的关键参与者的潜力，最终影响植物-真菌共生和生态系统功能。
