Khosla Sundeep
Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic and Foundation, 200 First Street SW, 5-194 Joseph, Rochester, MN 55905, USA.
Trends Pharmacol Sci. 2003 Jun;24(6):261-3. doi: 10.1016/S0165-6147(03)00124-X.
Estrogen, the traditional treatment of both short- and long-term consequences of the menopause, has fallen into disfavor. Thus, selective estrogen receptor modulators (SERMs) have been used as an alternative approach to activate estrogen signaling pathways in a tissue-specific manner. In addition, recent findings indicate that some compounds might activate specific estrogen signaling pathways that are beneficial without affecting other pathways that might lead to the harmful side-effects associated with estrogen. These so-called mechanism-specific ligands of estrogen or androgen receptors hold considerable promise as novel approaches to treat (or at least ameliorate) the consequences of estrogen deficiency.
雌激素，这种用于治疗更年期短期和长期后果的传统疗法，已失宠。因此，选择性雌激素受体调节剂（SERM）已被用作一种替代方法，以组织特异性方式激活雌激素信号通路。此外，最近的研究结果表明，一些化合物可能激活特定的雌激素信号通路，这些通路有益，同时不会影响其他可能导致与雌激素相关有害副作用的通路。这些所谓的雌激素或雄激素受体的机制特异性配体，作为治疗（或至少改善）雌激素缺乏后果的新方法，具有很大的前景。
