雌激素受体：新千年的新方向。
Estrogen Receptors: New Directions in the New Millennium.
机构信息
Receptor Biology Section, Reproductive and Developmental Endocrinology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
出版信息
Endocr Rev. 2018 Oct 1;39(5):664-675. doi: 10.1210/er.2018-00087.
Abstract
Nineteen years have passed since our previous review in this journal in 1999 regarding estrogen receptors. At that time, we described the current assessments of the physiological activities of estrogen and estrogen receptors. Since that time there has been an explosion of progress in our understanding of details of estrogen receptor-mediated processes from the molecular and cellular level to the whole organism. In this review we discuss the basic understanding of estrogen signaling and then elaborate on the progress and current understanding of estrogen receptor actions that have developed using new models and continuing clinical studies.
摘要
自 1999 年我们在本期刊上发表关于雌激素受体的上一篇综述以来，已经过去了 19 年。当时，我们描述了目前对雌激素和雌激素受体生理活性的评估。从那时起，我们对雌激素受体介导的过程从分子和细胞水平到整个生物体的细节的理解有了爆炸式的进展。在这篇综述中，我们讨论了对雌激素信号的基本理解，然后详细阐述了使用新模型和不断进行的临床研究发展起来的雌激素受体作用的进展和当前认识。
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