Liang Mike P, Banatao D Rey, Klein Teri E, Brutlag Douglas L, Altman Russ B
Department of Genetics and Stanford Medical Informatics, 251 Campus Drive, Stanford University, Stanford, CA 94305, USA.
Nucleic Acids Res. 2003 Jul 1;31(13):3324-7. doi: 10.1093/nar/gkg553.
WebFEATURE (http://feature.stanford.edu/webfeature/) is a web-accessible structural analysis tool that allows users to scan query structures for functional sites in both proteins and nucleic acids. WebFEATURE is the public interface to the scanning algorithm of the FEATURE package, a supervised learning algorithm for creating and identifying 3D, physicochemical motifs in molecular structures. Given an input structure or Protein Data Bank identifier (PDB ID), and a statistical model of a functional site, WebFEATURE will return rank-scored 'hits' in 3D space that identify regions in the structure where similar distributions of physicochemical properties occur relative to the site model. Users can visualize and interactively manipulate scored hits and the query structure in web browsers that support the Chime plug-in. Alternatively, results can be downloaded and visualized through other freely available molecular modeling tools, like RasMol, PyMOL and Chimera. A major application of WebFEATURE is in rapid annotation of function to structures in the context of structural genomics.
WebFEATURE（http://feature.stanford.edu/webfeature/）是一个可通过网络访问的结构分析工具，它允许用户扫描查询结构，以查找蛋白质和核酸中的功能位点。WebFEATURE是FEATURE软件包扫描算法的公共接口，FEATURE软件包是一种监督学习算法，用于在分子结构中创建和识别三维物理化学基序。给定一个输入结构或蛋白质数据库标识符（PDB ID）以及一个功能位点的统计模型，WebFEATURE将在三维空间中返回排名得分的“命中结果”，这些结果可识别出结构中相对于位点模型发生类似物理化学性质分布的区域。用户可以在支持Chime插件的网络浏览器中可视化并交互式地操作得分的命中结果和查询结构。或者，结果可以通过其他免费的分子建模工具（如RasMol、PyMOL和Chimera）进行下载和可视化。WebFEATURE的一个主要应用是在结构基因组学背景下对结构的功能进行快速注释。
