Adjei Andrew Anthony, Adiku Theophilus Korku, Kumi Patrick Ferdinand Ayeh, Domfeh Akosua Benefah
Department of Pathology, University of Ghana Medical School, Accra, Ghana.
Jpn J Infect Dis. 2003 Apr;56(2):57-9.
Serum samples from 124 acquired immunodeficiency syndrome (AIDS) hospitalized patients at the Fevers Unit, Korle-Bu Teaching Hospital, Accra, Ghana, were examined by the particle agglutination test for antibodies to human T-lymphotropic virus type 1 (HTLV-1) core proteins. The subjects included 84 males and 40 females, aged 16 to 54 years. Specific antibodies were detected in only 14 out of the 124 sera samples, giving an overall prevalence rate of 11.29%. The incidence was lower in males (5.95%; 5/84) than in females (22.50%; 9/40) (P<0.05). In both sexes, the age distribution of subjects positive for HTLV-1 antibodies ranged from 35 to 54 years. The prevalence rate reported herein is too low to suggest an association of HTLV-1 with AIDS, though it may indicate an opportunistic infection of AIDS patients by HTLV-1. Whether HTLV-1 is an underlying disease association or whether HTLV-1 plays some auxiliary role in the acquisition and progression of AIDS remains to be determined.
对加纳阿克拉科尔勒-布教学医院发热病房收治的124例获得性免疫缺陷综合征（AIDS）住院患者的血清样本进行了检测，采用颗粒凝集试验检测抗人类嗜T淋巴细胞病毒1型（HTLV-1）核心蛋白抗体。研究对象包括84名男性和40名女性，年龄在16至54岁之间。在124份血清样本中，仅14份检测到特异性抗体，总体患病率为11.29%。男性的发病率（5.95%；5/84）低于女性（22.50%；9/40）（P<0.05）。在男女两性中，HTLV-1抗体阳性受试者的年龄分布在35至54岁之间。本文报道的患病率过低，无法表明HTLV-1与AIDS之间存在关联，不过这可能表明AIDS患者受到了HTLV-1的机会性感染。HTLV-1是一种潜在的疾病关联因素，还是在AIDS的获得和进展中发挥某种辅助作用，仍有待确定。
