Kagerer Sabine, Winter Catja, Möller Hans-Jürgen, Soyka Michael
Psychiatric Hospital, Dtstion C4, University of Munich, Nussbaumstrasse 7, DE-80336 Munich, Germany.
Neuropsychobiology. 2003;47(4):212-8. doi: 10.1159/000071217.
The influence of antipsychotic treatment on the neuropsychological and psychomotor performance of schizophrenic patients is still a subject of investigation. The present study was designed to evaluate the effects of atypical neuroleptics in comparison with a conventional dopamine antagonist neuroleptic (haloperidol) on several dimensions of psychomotor performance (visual perception, attention, reaction time, and sensorimotor performance) considered to be of relevance in evaluating driving fitness. Psychomotor performance was assessed by means of the ART 90, a computerized Act and React Test which is generally used in diagnosis of psychomotor performance. The 49 participating patients were examined at discharge following psychopathological stabilisation; 20 received haloperidol, 29 received an atypical neuroleptic. Our findings demonstrate a remarkably reduced psychomotor performance in the haloperidol-treated group of schizophrenic patients compared with patients treated with atypical neuroleptics. Only 1 (5%) subject passed all subtests without major failures and could be regarded as competent to drive. Among patients with atypical neuroleptics, 7 patients (24%) passed all test parameters without major failures.
抗精神病药物治疗对精神分裂症患者神经心理和精神运动表现的影响仍是一个研究课题。本研究旨在评估非典型抗精神病药物与传统多巴胺拮抗剂（氟哌啶醇）相比，对精神运动表现的几个维度（视觉感知、注意力、反应时间和感觉运动表现）的影响，这些维度被认为与评估驾驶适宜性相关。精神运动表现通过ART 90进行评估，这是一种计算机化的行为与反应测试，通常用于精神运动表现的诊断。49名参与研究的患者在精神病理状态稳定后出院时接受了检查；20名患者接受氟哌啶醇治疗，29名患者接受非典型抗精神病药物治疗。我们的研究结果表明，与接受非典型抗精神病药物治疗的患者相比，接受氟哌啶醇治疗的精神分裂症患者组的精神运动表现显著降低。只有1名（5%）受试者通过了所有子测试且无重大失误，可被视为具备驾驶能力。在接受非典型抗精神病药物治疗的患者中，7名患者（24%）通过了所有测试参数且无重大失误。
