Prenner Jonathan L, Rosenblatt Brett J, Tolentino Michael J, Ying Gui-Shang, Javornik Norren B, Maguire Maureen G, Ho Allen C
Associated Retinal Consultants, Royal Oak, Michigan, USA.
Retina. 2003 Jun;23(3):307-14. doi: 10.1097/00006982-200306000-00004.
To identify risk factors for the development of choroidal neovascularization (CNV) and vision loss in the Fellow Eye Study of the Choroidal Neovascularization Prevention Trial.
Retrospective review of 121 patients enrolled in a multicentered, randomized, controlled trial. Patients had neovascular age-related macular degeneration in one eye and more than 10 large drusen in the other eye. Records of patients randomly assigned to laser treatment or observation were reviewed through 4 years of follow-up. Three candidate risk factors for the development of CNV and vision loss were evaluated.
Eyes with hyperfluorescent drusen on fluorescein angiography at 3 minutes appeared to have a decreased risk of CNV. Patchy choroidal filling was seen in 14% of patients. Eyes with patchy choroidal perfusion showed a higher risk of developing CNV that was not statistically significant, and the increased risk was present only in treated eyes. Reticular pseudodrusen were present in only three eyes.
Reticular pseudodrusen were rare. Late drusen fluorescence may protect against the development of CNV.
在脉络膜新生血管预防试验的对侧眼研究中确定脉络膜新生血管（CNV）发生及视力丧失的危险因素。
对121例参加多中心、随机、对照试验的患者进行回顾性研究。患者一只眼睛患有新生血管性年龄相关性黄斑变性，另一只眼睛有10个以上的大玻璃膜疣。对随机分配接受激光治疗或观察的患者记录进行了4年的随访。评估了CNV发生和视力丧失的三个候选危险因素。
在3分钟时荧光素血管造影显示有高荧光玻璃膜疣的眼睛似乎发生CNV的风险降低。14%的患者出现斑片状脉络膜充盈。有斑片状脉络膜灌注的眼睛发生CNV的风险较高，但无统计学意义，且增加的风险仅存在于接受治疗的眼睛中。仅三只眼睛出现网状假性玻璃膜疣。
网状假性玻璃膜疣罕见。晚期玻璃膜疣荧光可能预防CNV的发生。
