患有肾病综合征的高胆固醇血症儿童抗氧化活性降低。

Decreased antioxidant activity in hypercholesterolemic children with nephrotic syndrome.

作者信息

Zachwieja Jacek, Bobkowski Waldemar, Dobrowolska-Zachwieja Agnieszka, Zaniew Marcin, Maciejewski Janusz

机构信息

Department of Nephrology, Institute of Pediatrics, Medical University, Poznań, Poland.

出版信息

Med Sci Monit. 2003 Jun;9(6):CR235-9.

PMID:12824952

Abstract

BACKGROUND

The aim of the present study was to estimate the total antioxidant status (TAS) and main antioxidant enzyme activity in children with nephrotic syndrome (NS).

MATERIAL/METHODS: The study was carried out in a group of 82 children with NS, age 4-16 years (mean 7.4). Of these, 59 with a first episode formed group I, and 23 children in remission (>6 months, with no immunosuppressive treatment) formed group II. TAS was estimated using the two-reagent Randox Total Antioxidant Status test in plasma.

RESULTS

TAS was significantly reduced in group I compared to controls (0.77+/-0.14 mmol/l vs. 1.18+/-0.42 mmol/l; p<0.001). The TAS level was more reduced in those patients with higher total cholesterol (TChol) and low density lipoproteins cholesterol (LDL-cholesterol). In children from group I the activity of glutathione reductase (GR) was lower than in the controls (8.10+/-2.40 U/g Hb vs. 10.55+/-3.81 U/g Hb, p<0.001) and similarly the activity of glutathione peroxidase (GPX) was lower in group I compared to controls (28.65+/-6.99 U/g Hb vs. 33.84+/-13.11 U/g Hb, p=0.010). There was no significant difference in superoxide dismutase (SOD) activity between the 3 groups.

CONCLUSIONS

Reduced antioxidant activity may be related to lipid abnormalities in NS.

摘要

背景

本研究旨在评估肾病综合征（NS）患儿的总抗氧化状态（TAS）及主要抗氧化酶活性。

材料/方法：本研究纳入了82例4至16岁（平均7.4岁）的NS患儿。其中，59例首次发病的患儿组成I组，23例处于缓解期（>6个月，未接受免疫抑制治疗）的患儿组成II组。采用两试剂兰多克斯总抗氧化状态检测法评估血浆中的TAS。

结果

与对照组相比，I组的TAS显著降低（0.77±0.14 mmol/l对1.18±0.42 mmol/l；p<0.001）。总胆固醇（TChol）和低密度脂蛋白胆固醇（LDL-胆固醇）水平较高的患者TAS水平降低更明显。I组患儿的谷胱甘肽还原酶（GR）活性低于对照组（8.10±2.40 U/g Hb对10.55±3.81 U/g Hb，p<0.001），同样，I组的谷胱甘肽过氧化物酶（GPX）活性也低于对照组（28.65±6.99 U/g Hb对33.84±13.11 U/g Hb，p=0.010）。三组间超氧化物歧化酶（SOD）活性无显著差异。