Zachwieja J, Bobkowski W, Niklas A, Strzykała K, Maciejewski J
Kliniki Chorób Dzieci Instytutu Pediatrii Akademii Medycznej w Poznaniu.
Pol Merkur Lekarski. 2000 Apr;8(46):216-7.
The aim of the study was to estimate total antioxidant status (TAS) as the most reliable factor involved in antioxidant protection in children with nephrotic syndrome. 28 children with NS (12 with first episode and 16 with relapse NS) aged 4-16 were included into the study. TAS was estimated using two-regent Randox Total Antioxidant Status test in plasma. Laboratory investigations were performed before steroid treatment.
In children with NS reduced antioxidant protection is one of the factors leading to renal injury and may be a consequence a cause reason of lipids abnormalities.
本研究的目的是评估总抗氧化状态（TAS），其为参与肾病综合征患儿抗氧化保护的最可靠因素。28例4至16岁的肾病综合征患儿（12例初发，16例复发）纳入本研究。采用双试剂兰多克斯总抗氧化状态检测法评估血浆中的TAS。在类固醇治疗前进行实验室检查。
1）与对照组相比，肾病综合征患儿的TAS显著降低（0.81±0.14；1.21±0.62 mmol/L；p = 0.002）；2）发现总胆固醇（Tchol）、低密度脂蛋白（LDL）与TAS之间呈负相关（TAS与Tchol，p = 0.0005，R = 0.61；TAS与LDL，p = 0.03，R = 0.41）；3）肾病综合征初发患儿的TAS高于复发患儿（0.88±0.07；0.75±0.16 mmol/l；p = 0.14）。
在肾病综合征患儿中，抗氧化保护降低是导致肾损伤的因素之一，可能是脂质异常的一个后果或原因。
