Bodelsson G, Stjernquist M
Department of Obstetrics and Gynaecology, University of Lund, General Hospital, Malmö, Sweden.
Hum Reprod. 1992 Oct;7(9):1185-8. doi: 10.1093/oxfordjournals.humrep.a137823.
The relaxatory influences of substance P (SP), vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and atrial natriuretic peptide (ANP) were investigated in human uterine arteries precontracted by noradrenaline in vitro. SP, VIP, CGRP and ANP all relaxed isolated uterine arteries with intact endothelium. When tested on vessels devoid of their endothelium VIP and SP had no effect on smooth muscular tone, while ANP and CGRP still induced unchanged vasodilatation. These results suggest an involvement of an endothelium-derived relaxing substance in the mechanisms by which VIP and SP induce relaxation of the isolated human uterine artery. On the other hand, ANP and CGRP seem to act on the same vessel preparation in vitro independently of the vascular endothelium. Both addition of noradrenaline and exchange of sodium against potassium in the organ chambers resulted in smooth muscle contraction irrespective of the integrity of the endothelium.
在体外对去甲肾上腺素预收缩的人子宫动脉，研究了P物质（SP）、血管活性肠肽（VIP）、降钙素基因相关肽（CGRP）和心钠素（ANP）的舒张作用。SP、VIP、CGRP和ANP均可使具有完整内皮的离体子宫动脉舒张。当在去除内皮的血管上进行测试时，VIP和SP对平滑肌张力无影响，而ANP和CGRP仍可引起不变的血管舒张。这些结果表明，一种内皮源性舒张物质参与了VIP和SP诱导离体人子宫动脉舒张的机制。另一方面，ANP和CGRP似乎在体外对相同的血管标本起作用，而与血管内皮无关。在器官浴槽中加入去甲肾上腺素以及用钾离子交换钠离子，均可导致平滑肌收缩，而与内皮的完整性无关。
