Kumar Srinivas K, Hager Erin, Pettit Catherine, Gurulingappa Hallur, Davidson Nancy E, Khan Saeed R
Division of Experimental Therapeutics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.
J Med Chem. 2003 Jul 3;46(14):2813-5. doi: 10.1021/jm030213+.
A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.
合成了一系列硼酸查尔酮衍生物，并测试了它们对人乳腺癌细胞系的抗肿瘤活性。结果表明，与其他已知查尔酮相比，硼酸查尔酮对乳腺癌细胞的毒性比对正常乳腺细胞的毒性更大。
