Laboratory of Developing Drug Candidates, Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Agartala, Tripura, 799022, India.
Department of Microbiology and Biotechnology, School of Natural Sciences, Techno India University Tripura, Maheshkhola, Anandanagar, Agartala, Tripura, 799004, India.
Top Curr Chem (Cham). 2024 Jun 27;382(3):22. doi: 10.1007/s41061-024-00468-7.
Chalcone is a simple naturally occurring α,β-unsaturated ketone with biological importance, which can also be easily synthesized in laboratories by reaction between two aromatic scaffolds. In plants, chalcones occur as polyphenolic compounds of different frameworks which are bioactive molecules that have been in traditional medicinal practice for many years. Chalcone-based lead molecules have been developed, possessing varied potentials such as antimicrobial, antiviral, anti-inflammatory, anticancer, anti-oxidant, antidiabetic, antihyperurecemic, and anti-ulcer effects. Chalcones contribute considerable fragments to give important heterocyclic molecules with therapeutic utilities targeting various diseases. These characteristic features have made chalcone a topic of interest among researchers and have attracted investigations into this widely applicable structure. This review highlights the extensive exploration carried out on the synthesis, biotransformations, chemical reactions, hybridization, and pharmacological potentials of chalcones, and aims to provide an extensive, thorough, and critical review of their importance, with emphasis on their properties, chemistry, and biomedical applications to boost future investigations into this potential scaffold in medicinal chemistry.
查耳酮是一种具有生物学重要性的简单天然存在的α，β-不饱和酮，也可以通过两个芳基支架之间的反应在实验室中轻松合成。在植物中，查耳酮作为不同骨架的多酚化合物存在，是具有生物活性的分子，多年来一直用于传统医学实践。已经开发出基于查耳酮的先导分子，具有多种潜力，如抗菌、抗病毒、抗炎、抗癌、抗氧化、抗糖尿病、抗高尿酸血症和抗溃疡作用。查耳酮贡献了重要的片段，生成具有治疗各种疾病的治疗用途的重要杂环分子。这些特征使查耳酮成为研究人员关注的话题，并吸引了对这种广泛应用结构的研究。本综述重点介绍了对查耳酮的合成、生物转化、化学反应、杂交和药理学潜力的广泛探索，旨在对其重要性进行广泛、深入和批判性的综述，重点介绍其性质、化学和生物医学应用，以促进未来在药物化学中对这种潜在支架的研究。
