Rodríguez Manuel, Pereda Ernesto, González Julián, Abdala Patricio, Obeso Jose A
Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.
Synapse. 2003 Sep 15;49(4):216-25. doi: 10.1002/syn.10233.
The current model of the basal ganglia (BG) assumes that neurons use a firing rate renewal code for movement computing under normal and pathological conditions. Here, we report nonrenewal firing (neuronal firing is influenced by its own previous activity) in cells of the anesthetized rat's substantia nigra (SN). Both compensatory (short interspike intervals (ISIs) are followed by long ISIs and vice versa) and persistent (short and long ISIs cluster for long time periods) nonrenewal activity was found in 52.6% and 33.8% of SN cells, respectively. A compensatory pattern was found in 77.7% of DA cells, but in only 9.8% of GABA-cells. Conversely, a persistent pattern was observed in 74.6% of GABAergic cells and in only 9.9% of DA cells. These findings indicate two types of nonrenewal firing pattern codes specifically present in SN dopaminergic and GABAergic neurons. Disruption of these patterns may play a role in the pathophysiology of basal ganglia disorders such as Parkinson's disease and dyskinesias.
目前的基底神经节（BG）模型假定，在正常和病理条件下，神经元使用发放率更新编码来进行运动计算。在此，我们报告了麻醉大鼠黑质（SN）细胞中的非更新发放（神经元发放受其自身先前活动的影响）。在SN细胞中，分别有52.6%和33.8%的细胞发现了补偿性（短峰间间隔（ISI）之后是长ISI，反之亦然）和持续性（短ISI和长ISI长时间聚集）非更新活动。在77.7%的多巴胺能（DA）细胞中发现了补偿模式，但在仅9.8%的γ-氨基丁酸（GABA）能细胞中发现了该模式。相反，在74.6%的GABA能细胞中观察到了持续模式，而在仅9.9%的DA细胞中观察到了该模式。这些发现表明，在SN多巴胺能和GABA能神经元中特异性存在两种类型的非更新发放模式编码。这些模式的破坏可能在帕金森病和运动障碍等基底神经节疾病的病理生理学中起作用。
