一名抗体缺陷的阿根廷儿童因疫苗衍生脊髓灰质炎病毒引发麻痹性脊髓灰质炎。
Paralytic poliomyelitis caused by a vaccine-derived polio virus in an antibody-deficient Argentinean child.
作者信息
Hidalgo Solange, García Erro Marcela, Cisterna Daniel, Freire M Cecilia
机构信息
National Polio Eradication Program, Neurology Service, Ricardo Gutiérrez Hospital for Children, Buenos Aires, Argentina.
出版信息
Pediatr Infect Dis J. 2003 Jun;22(6):570-2.
We describe a case of poliomyelitis in a 3-year-old Argentinean boy with X-linked hypogammaglobulinemia. The child had no history of polio vaccination, but a poliovirus isolated from a stool sample had 97.2% genetic similarity to the Sabin 1 vaccine strain. According to the WHO definition, this is the first case reported of a vaccine-derived poliovirus infection recorded in continental Latin America.
我们描述了一名患有X连锁低丙种球蛋白血症的3岁阿根廷男孩患小儿麻痹症的病例。该儿童没有接种脊髓灰质炎疫苗的病史，但从粪便样本中分离出的一株脊髓灰质炎病毒与萨宾1型疫苗株有97.2%的基因相似性。根据世界卫生组织的定义，这是拉丁美洲大陆报告的首例疫苗衍生脊髓灰质炎病毒感染病例。
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