Parvaneh Nima, Shahmahmoudi Shohreh, Tabatabai Hamideh, Zahraei Mohsen, Mousavi Taha, Esteghamati Abdol-Reza, Gooya Mohammad M, Mamishi Setareh, Nategh Rakhshandeh, Kew Olen M
Department of Pediatrics, Infectious Disease Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
J Clin Virol. 2007 Jun;39(2):145-8. doi: 10.1016/j.jcv.2007.04.002. Epub 2007 May 16.
Vaccine-associated paralytic poliomyelitis (VAPP) is a rare complication of oral polio vaccine. We describe a fatal case of VAPP in an 8-month-old boy with Major Histocompatibility Class II deficiency. The isolated poliovirus was a Sabin type 2-type 1 recombinant that showed 1.4% VP1 divergence from Sabin type 2.
疫苗相关麻痹型脊髓灰质炎（VAPP）是口服脊髓灰质炎疫苗的一种罕见并发症。我们描述了一例8个月大患有主要组织相容性复合体II类缺陷的男童发生VAPP致死的病例。分离出的脊髓灰质炎病毒是一种萨宾2型-1型重组病毒，与萨宾2型病毒在VP1上有1.4%的差异。
