Ito Yasuhiro, Yoshida Hiroshi, Shibahara Kotaro, Uruno Takashi, Nakano Keiichi, Takamura Yuuki, Miya Akihiro, Kobayashi Kaoru, Yokozawa Tamotsu, Matsuzuka Fumio, Uchimi Takeshi, Kuwano Michihiko, Miyoshi Eiji, Matsuura Nariaki, Kuma Kanji, Miyauchi Akira
Department of Surgery, Kuma Hospital, Kobe, Japan.
Pathol Int. 2003 Jul;53(7):429-33. doi: 10.1046/j.1440-1827.2003.01494.x.
Recent studies have demonstrated that Y-box binding protein (YB-1) regulates the transcription of genes linked to carcinoma progression. In this study, we investigated the expression of this protein in thyroid neoplasms to elucidate its significance. The expression of YB-1 was immunohistochemically investigated using the monoclonal antibody for various thyroid neoplasms. Normal follicles did not overexpress YB-1, and only moderate overexpression of YB-1 was observed in some follicular tumors and papillary carcinoma, especially those of a larger size. In contrast, 92.9% of anaplastic carcinoma strongly overexpressed YB-1. YB-1 immunoreactivity was seen in both cytoplasms and cell nuclei, but the former was more predominant. These findings suggest that YB-1 plays a role in regulating the transcription as well as translation of genes contributing to the anaplastic transformation of thyroid carcinoma.
近期研究表明，Y盒结合蛋白（YB-1）可调节与癌进展相关基因的转录。在本研究中，我们调查了该蛋白在甲状腺肿瘤中的表达情况，以阐明其意义。使用针对各种甲状腺肿瘤的单克隆抗体，通过免疫组织化学方法研究了YB-1的表达。正常滤泡不发生YB-1的过表达，仅在一些滤泡性肿瘤和乳头状癌中观察到中等程度的过表达，尤其是较大尺寸的肿瘤。相比之下，92.9%的间变性癌强烈过表达YB-1。YB-1免疫反应性在细胞质和细胞核中均可见，但前者更为显著。这些发现表明，YB-1在调节促成甲状腺癌间变性转化的基因的转录及翻译过程中发挥作用。
