Holbrook M R, Kendall C H, Shaw P A V
Department of Histopathology, Leicester Royal Infirmary, Infirmary Square, Leicester, UK.
Cytopathology. 2003 Jun;14(3):121-5. doi: 10.1046/j.1365-2303.2003.00024.x.
A sample of 384 thyroid cytology specimens prepared by cytospin over a 2.5-year period was classified by original report into inadequate, non-neoplastic and suspicious of neoplasia or worse. This was then compared with subsequent histology. The resulting data showed an inadequacy rate of 33%, a sensitivity of 55%, a specificity of 59%, a positive predictive value of 64% and a negative predictive value of 93%. On review of the cytology, in knowledge of the subsequent histology, the maximum achievable results were determined to have a positive predictive value of 79% and a negative predictive value of 97%. No clinically significant adverse event was detected.
在2.5年的时间里，通过细胞离心机制备了384份甲状腺细胞学标本，根据原始报告将其分为不充分、非肿瘤性以及可疑肿瘤或更严重情况。然后将其与后续的组织学结果进行比较。所得数据显示，不充分率为33%，敏感性为55%，特异性为59%，阳性预测值为64%，阴性预测值为93%。在知晓后续组织学结果的情况下对细胞学检查进行回顾，确定最大可实现结果的阳性预测值为79%，阴性预测值为97%。未检测到具有临床意义的不良事件。
