Mamoon Nadira, Jamy Rabia, Khan Asna Haroon
Department of Histopathology, Shifa International Hospital, Islamabad.
J Pak Med Assoc. 2013 Sep;63(9):1120-3.
To assess the efficacy of fine needle aspiration cytology in the evaluation of thyroid lesions.
The retrospective study comprised data of all patients who presented for fine needle aspiration cytology at the Shifa International Hospital, Islamabad, between January 2009 and April 2011. The data was retrieved from the departmental records and the results were recorded. All cases who underwent subsequent surgery were also retrieved and histopathology results were compared with the cytology results. Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were calculated.
Of the 327 patients, the results were inconclusive in 18 (5.5%), benign in 230 (70.3%), suspicious in 64 (19.6%) and malignant in 15 (4.6%) cases. Besides, 59 (18%) of these patients underwent subsequent surgery. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of fine needle aspiration cytology was calculated to be 85.7%, 73.3%, 50%, 94.2% and 76.2% respectively.
Fine needle aspiration cytology is a reasonably sensitive, specific and accurate initial diagnostic test for pre-operative evaluation of patients with thyroid swellings. The clinicians should be encouraged to use the procedure as it is minimally invasive and easily performed in an outpatient setting.
评估细针穿刺细胞学检查在甲状腺病变评估中的疗效。
这项回顾性研究纳入了2009年1月至2011年4月期间在伊斯兰堡希法国际医院接受细针穿刺细胞学检查的所有患者的数据。数据从科室记录中获取并记录结果。所有接受后续手术的病例也被纳入，将组织病理学结果与细胞学结果进行比较。计算敏感性、特异性、阳性预测值、阴性预测值和诊断准确性。
在327例患者中，18例（5.5%）结果不明确，230例（70.3%）为良性，64例（19.6%）可疑，15例（4.6%）为恶性。此外，这些患者中有59例（18%）接受了后续手术。细针穿刺细胞学检查的敏感性、特异性、阳性预测值、阴性预测值和准确性分别计算为85.7%、73.3%、50%、94.2%和76.2%。
细针穿刺细胞学检查是一种对甲状腺肿大患者进行术前评估的相当敏感、特异且准确的初步诊断方法。应鼓励临床医生采用该方法，因为它微创且易于在门诊进行。
