Henry C Jeya K, Lightowler Helen J, Marchini Jonathan
Nutrition and Food Science Group, School of Biological and Molecular Sciences, Oxford Brookes University, Gipsy Lane Campus, Headington, OX3 0BP.
Br J Nutr. 2003 Jun;89(6):811-7. doi: 10.1079/BJN2003839.
Little information exists on the extent of day-to-day intra-individual variation in resting metabolic rate (RMR) in women. The present study has investigated the intra-individual variation in RMR of women during the menstrual cycle. Nineteen women (naturally cycling non-pill users) were recruited to the study. Anthropometric and RMR measurements were taken at least three times per week for the duration of one complete menstrual cycle; measurements were taken for a second, consecutive cycle in eight of the nineteen subjects. RMR was measured by indirect calorimetry using a ventilated hood system under standardized conditions. The measurements made throughout each complete menstrual cycle were averaged and the levels of inter- and intra-individual variation in RMR were assessed by determining the CV (%). Mean RMR of the group was 5686 (sd 674) kJ/d; inter-individual variation in RMR was 11.8 %. There were wide differences in the intra-individual variation in RMR of women (CV range 1.7-10.4 %). The CV in ten subjects was small (2-4 %), while the CV in nine women was high (5-10 %), indicating a significant variation in RMR during the menstrual cycle in certain subjects. Using statistical models, it has been shown that there was a significant effect on RMR due to a subject-specific level of variability; this was the case even when accounting for a possible training effect. In conclusion, the findings from our present study show that RMR cannot be assumed to be 'stable' in all women. The implications of intra-individual variation in RMR and its impact on energy balance needs further research.
关于女性静息代谢率（RMR）的日常个体内差异程度，目前所知信息甚少。本研究调查了女性在月经周期中RMR的个体内差异。19名女性（自然月经周期且不服用避孕药者）被招募到本研究中。在一个完整月经周期内，每周至少进行三次人体测量和RMR测量；19名受试者中的8名连续进行了第二个月经周期的测量。RMR通过在标准化条件下使用通风面罩系统的间接量热法进行测量。对每个完整月经周期的测量值进行平均，并通过计算CV（%）来评估RMR的个体间和个体内差异水平。该组的平均RMR为5686（标准差674）kJ/天；RMR的个体间差异为11.8%。女性RMR的个体内差异存在很大差异（CV范围为1.7 - 10.4%）。10名受试者的CV较小（2 - 4%），而9名女性的CV较高（5 - 10%），这表明某些受试者在月经周期中RMR存在显著差异。使用统计模型表明，由于个体特异性的变异性水平，对RMR有显著影响；即使考虑到可能的训练效应，情况依然如此。总之，我们目前的研究结果表明，不能认为所有女性的RMR都是“稳定的”。RMR个体内差异及其对能量平衡的影响需要进一步研究。
