Harada T, Shinohara M, Nakamura S, Shimada M, Oka M
Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kyushu University, Fukuoka, Japan.
Int J Oral Maxillofac Surg. 1992 Dec;21(6):346-9. doi: 10.1016/s0901-5027(05)80759-3.
An expression of desmosomal glycoprotein 1 (DG 1) was immunohistochemically examined in 77 biopsies and 21 metastatic cervical lymph nodes of oral squamous cell carcinomas (SCC). In the primary tumors the DG 1 expression was significantly reduced at the invasive site of poorly differentiated and highly invasive tumors. In cases of metastases in cervical lymph nodes, the DG 1 staining at the invasive site of the primary tumor was significantly less than that of nonmetastatic cases. The DG 1 expression in the metastatic lymph nodes was as weak as that in the primary tumor. Thus, we suggest that immunohistochemical investigation of DG 1 expression in oral SCC is valuable in predicting tumor behavior.
采用免疫组织化学方法检测了77例口腔鳞状细胞癌（SCC）活检组织及21例转移性颈部淋巴结中桥粒糖蛋白1（DG 1）的表达情况。在原发性肿瘤中，低分化和高侵袭性肿瘤的侵袭部位DG 1表达显著降低。在颈部淋巴结转移病例中，原发性肿瘤侵袭部位的DG 1染色明显少于非转移病例。转移性淋巴结中的DG 1表达与原发性肿瘤中的表达一样弱。因此，我们认为对口腔SCC中DG 1表达进行免疫组织化学研究对预测肿瘤行为具有重要价值。
