成年大鼠脑中包含鸟嘌呤核苷酸交换因子的FERM结构域mRNA的表达。

Expression of FERM domain including guanine nucleotide exchange factor mRNA in adult rat brain.

作者信息

Madura Tomas, Yamashita Toshihide, Kubo Tateki, Taniguchi Manabu, Kawakita Akihiro, Hosokawa Ko, Tohyama Masaya

机构信息

Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

出版信息

Brain Res Mol Brain Res. 2003 Jun 10;114(2):163-7. doi: 10.1016/s0169-328x(03)00166-9.

DOI:10.1016/s0169-328x(03)00166-9

PMID:12829327

Abstract

FERM domain including Rho GEF (FIR) belongs to Dbl family of guanine nucleotide exchange factors and specifically activates biochemical pathways specific for Rac1. FIR was shown to regulate neurite remodeling of the embryonic neurons. Here we report a distribution of FIR mRNA in adult rat brain using in situ hybridization. The expression was found all throughout the brain with the most intensive signals in hippocampus, piriform cortex, red nucleus and nuclei of cranial nerves. The signal was predominantly localized in the neuronal cells.

摘要

含Rho鸟嘌呤核苷酸交换因子的FERM结构域（FIR）属于鸟嘌呤核苷酸交换因子的Dbl家族，可特异性激活Rac1特有的生化途径。FIR已被证明可调节胚胎神经元的神经突重塑。在此，我们利用原位杂交技术报道了FIR mRNA在成年大鼠脑中的分布情况。在整个大脑中均发现有表达，其中海马体、梨状皮质、红核和脑神经核中的信号最为强烈。信号主要定位于神经元细胞中。