Hamawy Majed M
Department of Surgery, University of Wisconsin, Madison, 53792, USA.
Transplantation. 2003 Jun 27;75(12):1921-7. doi: 10.1097/01.TP.0000070168.42915.47.
In the past two decades, an immense amount of information has been generated on the mechanism of T cell receptor (TCR) signaling (also called signal 1). This overview describes the major signalling pathways in the TCR signal transduction cascade and focuses on proximal events in TCR signaling. The review also discusses some of the strategies that target proximal TCR signaling, which are used for preventing graft rejection.
在过去二十年里，关于T细胞受体（TCR）信号传导机制（也称为信号1）已产生了大量信息。本综述描述了TCR信号转导级联反应中的主要信号通路，并着重介绍了TCR信号传导的近端事件。该综述还讨论了一些针对TCR近端信号传导的策略，这些策略被用于预防移植排斥反应。
