Bertoletti Antonio, Ferrari Carlo
Institute of Hepatology, University College London, Royal Free and University College of London Medical School, London, UK.
Hepatology. 2003 Jul;38(1):4-13. doi: 10.1053/jhep.2003.50310.
The innate immune system has a role not only in protecting the host during the initial period of virus infection, but also in shaping the nature of the adaptive immune response. In this review, we follow the kinetics of the virologic and immunologic events occurring from the time of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. We primarily discuss how the early events after infection might influence the development of the adaptive immune response in these 2 important viral infections and how new strategies for more efficient preventive and therapeutic vaccines can be derived from this knowledge.
先天免疫系统不仅在病毒感染初期保护宿主方面发挥作用，而且在塑造适应性免疫反应的性质方面也发挥作用。在这篇综述中，我们追踪了从感染乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）时起发生的病毒学和免疫学事件的动力学。我们主要讨论感染后的早期事件如何影响这两种重要病毒感染中适应性免疫反应的发展，以及如何从这一知识中得出更有效的预防性和治疗性疫苗的新策略。
