乙型肝炎病毒和丙型肝炎病毒感染的免疫学
Immunology of hepatitis B virus and hepatitis C virus infection.
作者信息
Rehermann Barbara, Nascimbeni Michelina
机构信息
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B16, 10 Center Drive, Bethesda, MD 20892, USA.
出版信息
Nat Rev Immunol. 2005 Mar;5(3):215-29. doi: 10.1038/nri1573.
More than 500 million people worldwide are persistently infected with the hepatitis B virus (HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease, cirrhosis and hepatocellular carcinoma. Despite many common features in the pathogenesis of HBV- and HCV-related liver disease, these viruses markedly differ in their virological properties and in their immune escape and survival strategies. This review assesses recent advances in our understanding of viral hepatitis, contrasts mechanisms of virus-host interaction in acute hepatitis B and hepatitis C, and outlines areas for future studies.
全球有超过5亿人持续感染乙型肝炎病毒（HBV）和/或丙型肝炎病毒（HCV），面临发展为慢性肝病、肝硬化和肝细胞癌的风险。尽管HBV和HCV相关肝病的发病机制有许多共同特征，但这些病毒在病毒学特性、免疫逃逸和生存策略方面存在显著差异。本综述评估了我们对病毒性肝炎理解的最新进展，对比了急性乙型肝炎和丙型肝炎中病毒与宿主相互作用的机制，并概述了未来研究的领域。
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