[局限于精囊的淀粉样变性：8例手术标本诊断病例的临床病理回顾]
[Amyloidosis localized in the seminal vesicles: clinico-pathological review of 8 cases diagnosed in surgical specimens].
作者信息
Caballero Martínez M Cristina, Gómez Dorronsoro M Luisa, Cuesta Alcalá José Angel, Amat Villegas Irene, Beloqui Pérez Raquel, Martínez Peñuela José M, Monzón Muñoz Francisco José
机构信息
Servicio de Anatomía Patológica, Hospital de Navarra, Pamplona, España.
出版信息
Arch Esp Urol. 2003 May;56(4):431-4.
OBJECTIVES
Clinical and pathological study of eight cases of localized amyloidosis of the seminal vesicles. Review of the literature.
METHODS
Immunohistochemical and histochemical study in surgical specimens.
RESULTS
Two of the eight cases studied for amyloidosis in seminal vesicles, were obtained from radical prostatectomy specimens; patients had prior androgen deprivation therapy for two months. Four cases were obtained from radical cistoprostatectomy specimens because of urothelial carcinoma and the last two cases were diagnosed by transrectal prostatic needle biopsy which including a portion of seminal vesicle. Amyloidosis of seminal the vesicle is permanganate-sensitive; A-Amyloid, laminin, amyloid P protein and collagen IV negative.
CONCLUSION
Localized amyloidosis ot the seminal vesicle is not an unusual finding. The incidence increases with age. The histochemical and immunohistochemical features are different from other amyloid deposits.
目的
对8例精囊局限性淀粉样变性进行临床和病理研究，并复习相关文献。
方法
对手术标本进行免疫组织化学和组织化学研究。
结果
8例精囊淀粉样变性研究中，2例取自前列腺根治性切除术标本，患者术前接受了2个月的雄激素剥夺治疗。4例因尿路上皮癌取自膀胱前列腺根治性切除术标本，最后2例经直肠前列腺穿刺活检诊断，其中包括部分精囊。精囊淀粉样变性对高锰酸钾敏感；A-淀粉样蛋白、层粘连蛋白、淀粉样P蛋白和IV型胶原均为阴性。
结论
精囊局限性淀粉样变性并非罕见发现。发病率随年龄增长而增加。其组织化学和免疫组织化学特征与其他淀粉样沉积物不同。
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