Molecular biology of leukemia.

OBJECTIVE

To review the current tests for diagnosis and the implications of cytogenetic analysis in leukemia.

DATA SOURCES

Professional journals, books.

CONCLUSION

Leukemia is a genetic disorder with more than 500 recurring translocations. Recurrent chromosomal changes occur in more than one half of all cases of leukemia. Testing includes bone marrow biopsy and aspirate, histochemical staining, immunophenotyping, cytogenetics, and molecular markers. Characterization of specific chromosome changes provides information in determining initial therapy and post-remission therapy.

IMPLICATIONS FOR NURSING PRACTICE

Nurses must continually educate themselves to stay current with developing technology and the results of continuing research. This professional education must then be translated to the bedside throughout the continuum of care.