Liu Yu-sheng, Huang Wei-fen, Li Li-ping, Zhong Chong-fa, Dong Rong-di, Sun Hong-yi
Institute of Space Medico-Engineering, Beijing, China.
Space Med Med Eng (Beijing). 2003 Apr;16(2):96-9.
To observe the protective effects of exercise training during 21 d -6 degrees head down bed rest (HDBR) on bone loss.
Ten healthy young men were randomly divided into HDBR group and HD-BR exercise group, with 5 in each group. Both groups were exposed to -6 degrees head down bed rest for 21 d. The subjects in the exercise group performed exercise with a bicycle ergometer in supine position 1 h/d during bed rest. Femur bone mineral density (BMD), serum bone gla protein (BGP) as well as hydroxyproline/creatinine (HOP/Cr) were determined before and during 20 d HDBR.
As compared with the before HDBR values, average femur BMD decreased by 5.8% and 0.9% for HDBR group and HDBR and exercise group respectively. HOP/Cr significantly increased in the HDBR group and was significantly higher than the HDBR exercise group. BGP decreased in both groups with no significant difference.
Exercise during 21 d -6 degrees HDBR is beneficial in preventing bone loss.
观察21天-6°头低位卧床休息（HDBR）期间运动训练对骨质流失的保护作用。
将10名健康青年男性随机分为HDBR组和HDBR运动组，每组5人。两组均进行21天-6°头低位卧床休息。运动组受试者在卧床休息期间每天仰卧位使用自行车测力计运动1小时。在HDBR 20天前及期间测定股骨骨密度（BMD）、血清骨钙素（BGP）以及羟脯氨酸/肌酐（HOP/Cr）。
与HDBR前的值相比，HDBR组和HDBR运动组的平均股骨BMD分别下降了5.8%和0.9%。HDBR组HOP/Cr显著升高，且显著高于HDBR运动组。两组BGP均下降，差异无统计学意义。
21天-6°HDBR期间进行运动有利于预防骨质流失。
