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[心肌细胞自发搏动节律中的整数倍节律及其可能机制]

[Integer multiple rhythm in the spontaneous beating rhythm of cardiac myocytes and its possible mechanism].

作者信息

Liu Zhi-qiang, Gu Hua-guang, Yang Ming-hao, Yang Fen, Fan Shao-guang, Ren Wei

机构信息

Institute of Space Medico-Engineering, Beijing, China.

出版信息

Space Med Med Eng (Beijing). 2003 Apr;16(2):142-4.

PMID:12830840
Abstract

OBJECTIVE

To introduce the characteristics of the integer multiple rhythm of cultured cardiac myocytes and to explore the cause of its generation.

METHOD

Spontaneous beating rhythms of cultured cardiac myocytes were observed with photometry system and stochastic Chay model was used to simulate the experimental results.

RESULT

Integer multiple rhythm was observed in the experiment. This kind of rhythm is similar to phenomena of sinus arrest. The integer multiple rhythm similar to that of the experiments was simulated in stochastic Chay model, and was demonstrated to be induced by the mechanism of autonomous stochastic resonance.

CONCLUSION

The integer multiple rhythm observed in the experiment might be generated via the effect of autonomous stochastic resonance.

摘要

目的

介绍培养心肌细胞的整数倍节律特征,并探讨其产生原因。

方法

用光度测量系统观察培养心肌细胞的自发搏动节律,并用随机蔡氏模型模拟实验结果。

结果

实验中观察到整数倍节律。这种节律类似于窦性停搏现象。在随机蔡氏模型中模拟出了与实验相似的整数倍节律,并证明是由自主随机共振机制诱发的。

结论

实验中观察到的整数倍节律可能是通过自主随机共振效应产生的。

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