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纳米技术与医学。

Nanotechnology and medicine.

作者信息

Emerich Dwaine F, Thanos Christopher G

机构信息

Sertoli Technologies, Inc, 245 Armington Street, Cranston, RI 02905, USA.

出版信息

Expert Opin Biol Ther. 2003 Jul;3(4):655-63. doi: 10.1517/14712598.3.4.655.

Abstract

Nanotechnology, or systems/device manufacture at the molecular level, is a multidisciplinary scientific field undergoing explosive development. The genesis of nanotechnology can be traced to the promise of revolutionary advances across medicine, communications, genomics and robotics. On the surface, miniaturisation provides cost effective and more rapidly functioning mechanical, chemical and biological components. Less obvious though is the fact that nanometre sized objects also possess remarkable self-ordering and assembly behaviours under the control of forces quite different from macro objects. These unique behaviours are what make nanotechnology possible, and by increasing our understanding of these processes, new approaches to enhancing the quality of human life will surely be developed. A complete list of the potential applications of nanotechnology is too vast and diverse to discuss in detail, but without doubt one of the greatest values of nanotechnology will be in the development of new and effective medical treatments (i.e., nanomedicine). This review focuses on the potential of nanotechnology in medicine, including the development of nanoparticles for diagnostic and screening purposes, artificial receptors, DNA sequencing using nanopores, manufacture of unique drug delivery systems, gene therapy applications and the enablement of tissue engineering.

摘要

纳米技术,即分子水平上的系统/器件制造,是一个正在经历爆炸式发展的多学科科学领域。纳米技术的起源可以追溯到医学、通信、基因组学和机器人技术等领域取得革命性进展的前景。从表面上看,小型化提供了具有成本效益且运行速度更快的机械、化学和生物组件。然而,不太明显的是,纳米级物体在与宏观物体截然不同的力的控制下,也具有显著的自排序和组装行为。这些独特的行为使得纳米技术成为可能,通过增进我们对这些过程的理解,必将开发出提高人类生活质量的新方法。纳米技术潜在应用的完整清单过于庞大和多样,无法详细讨论,但毫无疑问,纳米技术的最大价值之一将在于开发新的有效医疗方法(即纳米医学)。本综述重点关注纳米技术在医学中的潜力,包括用于诊断和筛查目的的纳米颗粒的开发、人工受体、使用纳米孔的DNA测序、独特药物递送系统的制造、基因治疗应用以及组织工程的实现。

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