Wenger Tibor, Moldrich Gabriella, Furst Susanna
Department of Human Morphology and Developmental Biology, Semmelweis University, Tuzolto u. 58, PO Box 95, Budapest, Hungary.
Brain Res Bull. 2003 Jul 15;61(2):125-8. doi: 10.1016/s0361-9230(03)00081-9.
The expression of central cannabinoid (CB1) receptors in tyrosine hydroxylase (TH) containing neurones was demonstrated. Co-localisation was present in different brain areas responsible for reward-related mechanisms. The immunohistochemical investigations have shown that co-localisation is present in parts of mesolimbic-mesocortical dopaminergic system like nucleus accumbens (Nacb), ventral tegmental area (VTA), in the striatum, pyriform cortex, respectively. The results suggest a functional role of CB1 receptors in cannabis addiction by acting directly on reward-related structures.
已证实含酪氨酸羟化酶（TH）的神经元中存在中枢大麻素（CB1）受体的表达。在负责奖赏相关机制的不同脑区中存在共定位现象。免疫组织化学研究表明，共定位分别存在于中脑边缘 - 中脑皮质多巴胺能系统的部分区域，如伏隔核（Nacb）、腹侧被盖区（VTA）、纹状体、梨状皮质。结果表明CB1受体通过直接作用于奖赏相关结构在大麻成瘾中发挥功能作用。
