Center for BrainHealth, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX 75235, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jul 2;38(1):30-5. doi: 10.1016/j.pnpbp.2011.11.001. Epub 2011 Nov 9.
Cue-elicited craving or the intense desire to consume a substance following exposure to a conditioned drug cue is one of the primary behavioral symptoms of substance use disorders (SUDs). While the concept of cue-elicited craving is well characterized in alcohol and other substances of abuse, only recently has it been described in cannabis. A review of the extant literature has established that cue-elicited craving is a powerful reinforcer that contributes to drug-seeking for cannabis. Further, emergent research has begun to identify the neurobiological systems and neural mechanisms associated with this behavior. What research shows is that while theories of THC's effects on the dopaminergic-reward system remain divergent, cannabis cues elicit neural activation in the brain's reward network.
线索诱发的渴望或在接触到条件性药物线索后强烈渴望摄入物质，是物质使用障碍（SUD）的主要行为症状之一。虽然在酒精和其他滥用物质中，线索诱发的渴望的概念已经得到很好的描述，但直到最近才在大麻中被描述。对现有文献的综述已经确立，线索诱发的渴望是一种强大的强化物，导致大麻的觅药行为。此外，新兴的研究已经开始确定与这种行为相关的神经生物学系统和神经机制。研究表明，虽然关于 THC 对多巴胺能奖赏系统影响的理论仍然存在分歧，但大麻线索会引起大脑奖赏网络的神经激活。
