Stepanichev M Yu, Moiseeva Yu V, Lazareva N A, Onufriev M V, Gulyaeva N V
Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5a Butlerov Str., Moscow 117485, Russia.
Brain Res Bull. 2003 Jul 15;61(2):197-205. doi: 10.1016/s0361-9230(03)00118-7.
Ample experimental evidence indicates that intracerebral injection or infusion of amyloid-beta peptides (Abeta) to rodents induces learning and memory impairments as well as neurodegeneration in brain areas related to cognitive function. In the present study, we assessed the effects of a single intracerebroventricular (i.c.v.) injection of aggregated Abeta fragment (25-35) at a dose of 15nmol/rat on short-term and long-term memory in rats during the 6-month post-surgery period. The results demonstrate that Abeta(25-35)-induced memory impairments in spontaneous alternation behavior in a Y-maze at 17, 36, and 180 days after the surgery as well as in a social recognition task 110 days post-surgery. Abeta(25-35) also impaired spatial memory in an 8-arm radial maze, but did not influence performance of the step-down passive avoidance task. These results suggest that Abeta(25-35) preferably induces impairments of spatial and non-spatial short-term (working) memory rather than long-term memory in rats.
大量实验证据表明，向啮齿动物脑内注射或输注β-淀粉样肽（Aβ）会导致学习和记忆障碍，以及与认知功能相关脑区的神经退行性变。在本研究中，我们评估了以15nmol/大鼠的剂量单次脑室内（i.c.v.）注射聚集的Aβ片段（25-35）对大鼠术后6个月内短期和长期记忆的影响。结果表明，Aβ（25-35）在术后17、36和180天诱导Y迷宫自发交替行为的记忆障碍，以及在术后110天的社会识别任务中诱导记忆障碍。Aβ（25-35）还损害了八臂放射状迷宫中的空间记忆，但不影响被动回避任务的表现。这些结果表明，Aβ（25-35）在大鼠中更倾向于诱导空间和非空间短期（工作）记忆障碍，而非长期记忆障碍。
