Donhuijsen K, Nabavi D, Leder L D
Universitätsinstitut für Pathologie, Essen.
Verh Dtsch Ges Pathol. 1992;76:117-21.
In order to identify histological and immunohistochemical criteria of prognostic value in AILD 40 lymph nodes with typical and 15 cases with incomplete features were semiquantitatively analyzed. Their expression were correlated with survival data of all patients. Significant prognostic value could be detected for following parameters: mitoses, immunoblasts, CD 30-positive blasts, multinuclear tumor cells and eosinophilic granulocytes. However residual lymph node structures, venules, PAS-positive material, and reticulum cells did not correlate with survival data. The short median survival time does not justify AILD grouping as low grade malignant lymphoma.
为了确定自身免疫性淋巴增生性疾病(AILD)中具有预后价值的组织学和免疫组化标准,对40个具有典型特征的淋巴结和15个具有不完全特征的病例进行了半定量分析。它们的表达与所有患者的生存数据相关。对于以下参数可检测到显著的预后价值:有丝分裂、免疫母细胞、CD30阳性母细胞、多核肿瘤细胞和嗜酸性粒细胞。然而,残留的淋巴结结构、小静脉、PAS阳性物质和网状细胞与生存数据无关。较短的中位生存时间不足以将AILD归类为低级别恶性淋巴瘤。