Paulus W, Jellinger K, Hallas C, Gärtner C, Kretschmer C, Ott G, Müller-Hermelink H K
Pathologisches Institut, Universität Würzburg.
Verh Dtsch Ges Pathol. 1992;76:207-10.
Fourty-three primary cerebral lymphomas (PCL) were histologically classified and examined for genome expression of Epstein Barr Virus (EBV) and human herpes virus 6 (HHV6) using dot blotting, polymerase chain reaction, and Southern blotting. Only 20 tumors (16 high grade and 4 low grade lymphomas) could be suitably placed into a category of the Updated Kiel Classification, whereas the non-classified 23 tumors were highly malignant B-lymphomas and referred to as small-cell (SC) or large-cell (LC) blastic PCL. Most of the LC PCL showed a tumor-like infiltration pattern with high cellular density and little remaining parenchyma, whereas the SC PCL more often showed an inflammation-like pattern characterized by loose arrangement of tumor cells and marked astrocytic, microglial and T-lymphocytic reaction. EBV genome was found in 3/3 AIDS cases, but in none of 40 immunocompetent cases, while HHV6 was detected in 2 tumors of immunocompetent patients. We conclude that (1) the Updated Kiel Classification is not applicable to a majority of PCL, and (2) EBV and HHV6 do not appear to play a major role in the pathogenesis of PCL in immunocompetent subjects.
对43例原发性脑淋巴瘤（PCL）进行组织学分类，并采用斑点杂交、聚合酶链反应和Southern杂交技术检测爱泼斯坦-巴尔病毒（EBV）和人类疱疹病毒6型（HHV6）的基因组表达。只有20例肿瘤（16例高级别和4例低级别淋巴瘤）能够适当地归入更新后的基尔分类的某一类别，而其余23例未分类的肿瘤为高度恶性B淋巴瘤，称为小细胞（SC）或大细胞（LC）母细胞性PCL。大多数LC PCL表现为肿瘤样浸润模式，细胞密度高，实质残留少，而SC PCL更常表现为炎症样模式，其特征为肿瘤细胞排列疏松，伴有明显的星形细胞、小胶质细胞和T淋巴细胞反应。在3例艾滋病病例中发现了EBV基因组，但在40例免疫功能正常的病例中均未发现，而在2例免疫功能正常患者的肿瘤中检测到了HHV6。我们得出结论：（1）更新后的基尔分类不适用于大多数PCL；（2）EBV和HHV6似乎在免疫功能正常的受试者PCL的发病机制中不起主要作用。
